OPPOSING EFFECTS OF INTERLEUKIN-10 ON MOUSE MACROPHAGE FUNCTIONS

• Type: Article in International Scientific Journal
• Date: 1995

Authors

APPELBERG, R (Author) ICBAS

Journal

Title: Scandinavian Journal of Immunology

Vol. 41

Pages: 539-544

ISSN: 0300-9475

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 23 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-GVM

DOI: 10.1111/j.1365-3083.1995.tb03605.x

Abstract (EN): Interleukin (IL)-10 generally is considered a macrophage deactivating factor and thus inhibits the cell-mediated responses against intracellular parasites. We evaluated the in vitro effects of IL-10 on three different parameters of macrophage function. We found that IL-10 inhibited gamma interferon (IFN-gamma) priming for enhanced O-2(-) release of mouse bone marrow-derived macrophages but had opposing effects on NO2- secretion according to the sequence of the treatment with IL-10 and the agonists of NO2- secretion. Likewise, IL-10 was able to induce a small but consistent degree of bacteriostasis of Mycobacterium avium and, also, to inhibit the bacteriostasis induced by IFN-gamma. Thus, we show that, according to the timing of exposure of macrophages to stimulating and inhibiting cytokines and agonists of their functions, IL-10 shows different effects on macrophage function.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6