CD40 is required for the optimal induction of protective immunity to Mycobacterium avium

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Florido, M (Author) Other; Goncalves, AS (Author) Other; Gomes, MS (Author) ICBAS; Appelberg, R (Author) ICBAS

Journal

Title: Immunology

Vol. 111

Pages: 323-327

ISSN: 0019-2805

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 18 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-BD1

DOI: 10.1111/j.1365-2567.2004.01812.x

Abstract (EN): C57Bl/6 mice and mice deficient in the CD40 molecule were infected with three strains of Mycobacterium avium. Two of the M. avium strains proliferated more extensively in CD40-deficient (CD40(-/-)) mice than in control mice. The increased susceptibility to infection of CD40(-/-) mice was associated with the generation of poorer interleukin-12 (IL-12) p40 and interferon-gamma (IFN-gamma) responses as compared to the controls, suggesting a role for CD40 in the development of protective immunity. In contrast, direct triggering of CD40 on infected macrophages failed to induce any anti-mycobacterial activity in infected macrophages.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5