Xanthohumol Modulates Inflammation, Oxidative Stress, and Angiogenesis in Type 1 Diabetic Rat Skin Wound Healing

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Raquel Costa (Author) Other; Rita Negrao (Author) FMUP; Ines Valente (Author) Other; Angela Castela (Author) Other; Delfim Duarte (Author) Other; Luisa Guardao (Author) Other; Paulo J Magalhaes (Author) Other; Jose A Rodrigues (Author) FCUP; Joao T Guimaraes (Author) FMUP; Pedro Gomes (Author) Other; Raquel Soares (Author) FMUP

Journal

Title: Journal of Natural Products

Vol. 76

Pages: 2047-2053

ISSN: 0163-3864

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 64 Citations

Scopus - 67 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-006-JNQ

DOI: 10.1021/np4002898

Abstract (EN): Type 1 diabetes mellitus is responsible for metabolic dysfunction, accompanied by chronic inflammation, oxidative stress, and endothelium dysfunction, and is often associated with impaired wound healing. Phenol-rich food improves vascular function, contributing to diabetes prevention. This study has evaluated the effect of phenol-rich beverage consumption in diabetic rats on wound healing, through angiogenesis, inflammation, and oxidative stress modulation. A wound-healing assay was performed in streptozotocin-induced diabetic Wistar rats drinking water, 5% ethanol, and stout beer with and without 10 mg/L xanthohumol (1), for a five-week period. Wounded skin microvessel density was reduced to normal values upon consumption of 1 in diabetic rats, being accompanied by decreased serum VEGF-A and inflammatory markers (IL-1 beta, NO, N-acetylglucosaminidase). Systemic glutathione and kidney and liver H2O2, 3-nitrotyrosine, and protein carbonylation also decreased to healthy levels after treatment with 1, implying an improvement in oxidative stress status. These findings suggest that consumption of xanthohumol (1) by diabetic animals consistently decreases inflammation and oxidative stress, allowing neovascularization control and improving diabetic wound healing.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7