Schizophrenia and cancer: Is angiogenesis a missed link?

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

lopes, r (Author) Other; soares, r (Author) FCNAUP; figueiredo-braga, m (Author) Other; coelho, r (Author) Other

Journal

Title: Life Sciences

Vol. 97

Pages: 91-95

ISSN: 0024-3205

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-009-5EH

DOI: 10.1016/j.lfs.2013.12.023

Abstract (EN): Cancer prevalence and risk in schizophrenia (SZ) patients, as well as their implicated molecular pathways, is a debate that has become increasingly appreciated, despite lacking evidence. Since angiogenesis is imbalanced in both conditions, a non-systematic review of the existing literature using the PubMed database was performed to summarize current knowledge and to elucidate hypothesis regarding the reduced incidence of cancer in SZ, exploring possible angiogenesis biology aspects that can be interrelated both with SZ and cancer. Some lines of evidence based in epidemiology, genetic, molecular and biochemical studies suggest a putative interplay between SZ pathophysiology and angiogenesis, involving different molecular pathways and also influencing cancer biology. Studying angiogenesis in SZ and its implications to cancer is an unexplored field that could provide more insightful knowledge regarding its pathophysiology and promote the development of treatment applications.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5