Increased circulating platelet microparticles as a potential biomarker in asthma

• Type: Article in International Scientific Journal
• Date: 2013

Authors

duarte, d (Author) Other; taveira-gomes, t (Author) Other; Sokhatska, O (Author) FMUP; palmares, c (Author) Other; costa, r (Author) Other; negrao, r (Author) FCNAUP; guimaraes, jt (Author) FCNAUP; delgado, l (Author) FMUP; soares, r (Author) FCNAUP; moreira, a (Author) FCNAUP

Journal

Title: Allergy: European Journal of Allergy and Clinical Immunology

Vol. 68

Pages: 1073-1075

ISSN: 0105-4538

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 44 Citations

Scopus - 44 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-006-8HW

DOI: 10.1111/all.12190

Abstract (EN): Background: Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. Methods: In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. Results: Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P=0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b--/AnV+) were significantly increased before (P=0.005) but not after adjustments (P=0.117). Conclusions: We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3