Assessment of Movement-Evoked Pain in Osteoarthritis by the Knee-Bend and CatWalk Tests: A Clinically Relevant Study

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Jose Castro Lopes (Author) FMUP; Ferreira-Gomes J. (Author) FMUP; Sara Adães (Author) Other

Journal

Title: Journal of Pain

Vol. 9

Pages: 945-954

ISSN: 1526-5900

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 78 Citations

Scopus - 79 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences

CORDIS: Health sciences ; Health sciences > Medical sciences > Medicine

Other information

Authenticus ID: P-003-VXA

DOI: 10.1016/j.jpain.2008.05.012

Abstract (EN): Although there are several reports on pain behavioral tests in rat models of knee osteoarthritis (OA), most of them focus on the paw. The aim of this study was to investigate pain-related behaviors on the affected knee joint, the primary source of nociception, in animals with mono-iodoacetate-induced OA, using the knee-bend (which provides information on movement pain) and pin-prick tests, and to evaluate nociception elicited by walking using the CatWalk test. The von Frey and Randall-Selitto tests applied to the paw allowed us to compare our study results with previous studies. A further aim was to compare the behavioral nociceptive responses of the most used doses of mono-iodoacetate, 2 and 3 mg. Knee-bend score of OA animals was higher than those of control animals throughout the study (P < .05). At every time point, the ipsilateral hind-paw load of OA rats, as measured by the CatWalk test, was lower than that of control rats (P < .05), and paw withdraw threshold to von Frey filaments was also decreased (P < .01). No changes were observed in pin-prick and Randall-Selitto tests. Results obtained with the 2 doses of mono-iodoacetate were similar. The knee-bend and CatWalk tests are effective for evaluating movement-related nociception, a hallmark of clinical CIA, which was present throughout the experimental period. Perspective: Behavioral characterization of models of OA pain is important and useful for use in future studies to test pharmacological treatments. Furthermore, it is important to find methods that correlate better with the human symptoms of OA. (C) 2008 by the American Pain Society

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10