Modified release of drug delivery systems: Hydrophilic polymers [Formas farmacêuticas de liberação modificada: Polímeros hidrifílicos]

• Type: Another Publication in an International Scientific Journal
• Date: 2005

Authors

lopes, cm (Author) Other; lobo, jms (Author) Other; costa, p (Author) FFUP

Journal

Title: Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences

Vol. 41

Pages: 143-154

ISSN: 1516-9332

Publisher: Universidade de São Paulo

Indexing

ISI Web of Knowledge

Scopus - 91 Citations

Other information

Authenticus ID: P-007-E5Z

Abstract (EN): Drug delivery systems (DDS) became an integral part of pharmaceutical research. The majority of oral DDS are matrix-based systems. Hydrophilic matrices for the past two decades have been popular in the formulation of controlled release solid dosage forms. Swellable matrices are monolithic systems prepared by compression of a powdered mixture of a hydrophilic polymer and a drug. They represent a delivery system in which various mechanisms can be adapted to the delivery program. Their success is linked to the established tabletting technology of manufacture. The choice of the hydrophilic polymer in the matrix formulation can provide an appropriate combination of swelling, dissolution or erosion mechanisms to evaluate in vitro release kinetics.

Language: Portuguese

Type (Professor's evaluation): Scientific

No. of pages: 12