Process intensification and optimization for hydroxyapatite nanoparticles production

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Filipa Castro (Author) FEUP; Simon Kuhn (Author) Other; Klavs Jensen (Author) Other; António Ferreira (Author) FEUP; Fernando Rocha (Author) FEUP; António Vicente (Author) Other; José António Teixeira (Author) Other

Journal

Title: Chemical Engineering Science

Vol. 100

Pages: 352-359

ISSN: 0009-2509

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 42 Citations

ISI Web of Science

Scopus - 46 Citations

INSPEC

Scientific classification

FOS: Engineering and technology > Chemical engineering

CORDIS: Technological sciences > Engineering > Chemical engineering

Associated Projects

UI0511 - PROJECTO ESTRATÉGICO - UI 511 - 2013-2014

Other information

Authenticus ID: P-006-83N

DOI: 10.1016/j.ces.2013.01.002

Abstract (EN): Precipitation processes are widely used in industry for the production of particulate solids. Efficient mixing of the reagents is of major importance for the chemical and physical nature of the synthesized particles. Recently, microreactors have been studied to overcome homogeneity problems found when using stirred tank batch reactors. The present work investigated an ultrasonic tubular microreactor for the continuous-flow precipitation of hydroxyapatite (HAp), both in single-phase flow (SPF) and in gas-liquid flow (GLF). HAp nanoparticles were yielded for both configurations under near-physiological conditions of pH and temperature. The as-prepared particles, especially those that were prepared under GLF, show improved characteristics compared to commercial powder or powder obtained in a stirred tank batch reactor. Primary particles are smaller, particle shape is more homogeneous, and the aggregation degree of the particles is lower.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8