QUINIDINE ION-SELECTIVE ELECTRODE FOR POTENTIOMETRIC DETERMINATIONS IN PHARMACEUTICAL PREPARATIONS

• Type: Article in International Scientific Journal
• Date: 1993

Authors

ALCADA, MNMP (Author) Other; LIMA, JLFC (Author) FFUP; MONTENEGRO, MCBSM (Author) FFUP

Journal

Title: Analytica Chimica Acta

Vol. 283

Pages: 657-661

ISSN: 0003-2670

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-001-MEQ

DOI: 10.1016/0003-2670(93)85279-s

Abstract (EN): The construction and evaluation of a quinidine ion-selective electrode, without an inner reference solution, based on an ion exchanger [quinidine tetrakis(4-chlorophenyl)borate] dissolved in 2-nitrophenyl octyl ether and immobilized in PVC is described. The prepared electrode showed a linear response in the concentration range 3 x 10(-5) - 1 x 10(-2) M in quinidine, with a slope of 57.5 mV per decade when the pH of the solutions was between 5 and 7.5. The reproducibility of the electrode was approximately +/- 1 mV during a day's work, with a response time of less than 10 s for quinidine concentrations between 10(-4) and 10(-2) M. The electrode was used for the direct potentiometric determination of quinidine in pharmaceutical preparations, giving results with an average recovery of 100.7% and a mean standard deviation of 2.3%.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5