PVC MEMBRANE-ELECTRODE WITHOUT INNER REFERENCE SOLUTION FOR THE DIRECT DETERMINATION OF EPHEDRINE IN PHARMACEUTICAL PREPARATIONS

• Type: Article in International Scientific Journal
• Date: 1992

Authors

ALCADA, MNMP (Author) Other; LIMA, JLFC (Author) FFUP; MONTENEGRO, MCB (Author) FFUP

Journal

Title: Journal of Pharmaceutical and Biomedical Analysis

Vol. 10

Pages: 757-761

ISSN: 0731-7085

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 14 Citations

Scopus - 17 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-001-P4T

DOI: 10.1016/0731-7085(91)80076-l

Abstract (EN): A PVC membrane electrode, without inner reference solution, based on an ion association extraction system responding to ephedrine is described. It incorporates an ephedrine-tetrakis (4-chlorophenyl)borate ion-pair complex in 2-nitrophenyloctyl ether. The prepared electrode exhibits a near Nernstian response (57.5 mV per decade) over the concentration range of 2 x 10(-5) 10(-1) M ephedrine in solutions of pH 2.5-9. The reproducibility of the electrode potentials were +/-1 mV by day during at least 6 months. Response time was about 6 s for ephedrine concentrations between 10(-5) and 10(-1) M. Determinations of ephedrine in pharmaceutical preparations (tablets, nasal drops and syrups) by direct potentiometry gave an average recovery of 99.1% (w/w) and a mean standard deviation of 1.9% (w/w).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5