CONSTRUCTION AND EVALUATION OF TETRAPHENYLBORATE ANION-SELECTIVE ELECTRODES - ITS APPLICATION IN DETERMINATION OF ALKALOIDS IN PHARMACEUTICAL PRODUCTS

• Type: Article in International Scientific Journal
• Date: 1994

Authors

ALCADA, MNMP (Author) FMUP; LIMA, JLFC (Author) FFUP; MONTENEGRO, MCBS (Author) FFUP

Journal

Title: Farmaco

Vol. 49

Pages: 721-726

ISSN: 0014-827X

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 3 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-JC6

Abstract (EN): This paper describes the construction and evaluation of tetraphenylborate ion selective electrodes (BPh4), using a PVC membrane without inner reference solution, based on tetrapentylammonium tetraphenylborate (TPABPh4) as ion-exchanger and 2-nitrophenylphenyl ether (NPPE) as solvent mediator. The electrodes show a linear response in BPh4 concentration range of 2.5 x 10(-6)-10(-1) M, and a slope of -55.6 mV/log[BPh4], in a pH range of approximately to 2.5-11.5 units. Variations in the potential of about +/-1 mV were registered during a working day. The response time was less than 3 seconds and the lifetime of the electrodes was superior to 18 months. Potentiometric titrations using these newly constructed electrodes were applied to several pharmaceutical preparations containing alkaloids, namely quinidine, pilocarpine and atropine. The results obtained present a mean recovery of 98.3+/-2.2%, 93.2+/-1.0% and 97.2+/-5.5% respectively. The method was adequate for routine laboratory analysis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6