FIA TITRATIONS OF EPHEDRINE IN PHARMACEUTICAL FORMULATIONS WITH A PVC TETRAPHENYLBORATE TUBULAR ELECTRODE

• Type: Article in International Scientific Journal
• Date: 1995

Authors

ALCADA, MNMP (Author) FMUP; LIMA, JLFC (Author) FFUP; MONTENEGRO, MCBSM (Author) FFUP

Journal

Title: Journal of Pharmaceutical and Biomedical Analysis

Vol. 13

Pages: 459-464

ISSN: 0731-7085

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 10 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-001-H4A

DOI: 10.1016/0731-7085(95)01323-d

Abstract (EN): A flow injection system for the titration of ephedrine in pharmaceutical products with potentiometric detection was developed. For this purpose a tetraphenylborate tubular electrode was constructed. The electrode was prepared without inner reference solution and with a PVC membrane based on tetrapentylammonium tetraphenylborate as ion exchanger and 2-nitrophenylphenyl ether as mediator solvent. Its operational characteristics were evaluated in a low dispersion manifold and compared with more conventionally shaped electrodes using the same sensor. In the pH range 2.5-11.5, the electrodes showed linear response between 3.8 x 10(-6) and 0.1 M with a slope of -56.4 mV/log[BPh4]. Ephedrine determinations in pharmaceutical products were carried out in a single channel manifold with a mixing chamber incorporated and using the tubular electrode as detector. Recovery rates of 98.6 +/- 2.5% were obtained in the analysis of tables, nasal drops and syrups with a sampling rate of about 60 h(-1).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6