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Anticomplementary activity of prenylated flavones from Artocarpus elasticus

Title
Anticomplementary activity of prenylated flavones from Artocarpus elasticus
Type
Article in International Scientific Journal
Year
1997
Authors
Nascimento, MSJ
(Author)
FFUP
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Cidade, H
(Author)
FFUP
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Pinto, M
(Author)
FFUP
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Kijjoa, A
(Author)
ICBAS
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Journal
Vol. 7
Pages: 135-137
ISSN: 0939-9488
Indexing
Publicação em ISI Web of Knowledge ISI Web of Knowledge
Other information
Authenticus ID: P-007-7C1
Abstract (EN): Artelastin, artelastochromene, artelasticin and artocarpesin, prenylated flavones previously isolated from Artocarpus elasticus, have shown a strong inhibition of the classical pathway (CP) of the human complement system. However, only artocarpesin showed an inhibitory effect on the alternative pathway (AP). Inhibitory effect of these flavonoids were dose dependent. Chelation of bivalent ions (Ca2+ or Mg2+) by these flavones can be responsible for their mode of action.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 3
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