Synthesis and antitumor evaluation of benzopsoralen analogues

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Ana M A G Oliveira (Author) Other; Ana M F Oliveira Campos (Author) Other; Ligia M Rodrigues (Author) Other; Manuela M M Raposo (Author) Other; Antonio E H Machado (Author) Other; Sao Jose Nascimento (Author) FFUP; Nazareth, N (Author) Other; Madalena Pinto (Author) FFUP

Journal

Title: Chemistry and Biodiversity

Vol. 4

Pages: 980-990

ISSN: 1612-1872

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 8 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-CQ2

DOI: 10.1002/cbdv.200790089

Abstract (EN): The synthesis of five new tetracyclic benzopsoralen analogues, compounds 2-6, with 9H-xanthen-9-one or 9H-carbazole frameworks, is described. Their inhibitory effects on the growth of three human tumor cell lines (MCF-7, SF-268, and NCI-460) were evaluated, and discussed in terms of structureactivity relationship, taking into account both geometric and electronic features. Generally, the angular compounds showed significant biological activities, but the arrangement of functional groups also contributed to the overall activity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11