Constituents of Schisandra verruculosa and their cytotoxic effect on human cancer cell lines

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Rujida Wilairat (Author) Other; Anake Kijjoa (Author) ICBAS; Madalena Pinto (Author) FFUP; Maria Sao Jose Nascimento (Author) FFUP; Artur M S Silva (Author) Other; Graham Eaton (Author) Other; Werner Herz (Author) Other

Journal

Title: Pharmaceutical Biology

Vol. 44

Pages: 411-415

ISSN: 1388-0209

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 5 Citations

Scientific classification

FOS: Engineering and technology > Medical engineering

Other information

Authenticus ID: P-004-HQ6

DOI: 10.1080/13880200600794105

Abstract (EN): 1,2-bis-(4-Hydroxy-3-methoxyphenyl)-3-hydroxypropan-1-one (evafolin B, 1), 1-(4-hydroxy-3-methoxyphenyl)-3-hydroxypropan-1-one (2), were isolated for the first time from the genus Schisandra, along with abscisic acid (3), 4-hydroxybenzaldehyde (4), 4-hydroxybenzoic acid (5), methyl 4-hydroxybenzoate (6), methyl 3,4-dihydroxybenzoate (7), and vanillic acid (8). All the compounds were evaluated for their antitumor, antiproliferative, and antioxidant activities. Only compound 7 exhibited moderate activity against three human cancer cell lines and human lymphocytic proliferation, as well as strong inhibitory activity for DPPH free radicals, only slightly less than ascorbic acid.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5