Synthesis of a Natural Chalcone and Its Prenyl Analogs - Evaluation of Tumor Cell Growth-Inhibitory Activities, and Effects on Cell Cycle and Apoptosis

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Marta P Neves (Author) Other; Raquel T Lima (Author) Other; Kanthima Choosang (Author) Other; Panee Pakkong (Author) Other; Maria de Sao Jose Nascimento (Author) FFUP; Helena Vasconcelos, MH (Author) FFUP; Madalena Pinto (Author) FFUP; Artur M S Silva (Author) Other; Honorina Cidade (Author) FFUP

Journal

Title: Chemistry and Biodiversity

Vol. 9

Pages: 1133-1143

ISSN: 1612-1872

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 24 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-002-9DJ

DOI: 10.1002/cbdv.201100190

Abstract (EN): Six prenyl (=3-methylbut-2-en-1-yl) chalcones (=1,3-diphenylprop-2-en-1-ones), 27, and one natural non-prenylated chalcone, 1, have been synthesized and evaluated for their in vitro growth-inhibitory activity against three human tumor cell lines. A pronounced dose-dependent growth-inhibitory effect was observed for all prenylated derivatives, except for 7. The chalcone possessing one prenyloxy group at C(2'), i.e., 2, was the most active derivative against the three human tumor cell lines (5.9<GI50<7.7 mu M). The majority of compounds caused an increase in percentage of apoptotic cells and/or they interfered with cell cycle distribution in the MCF-7 cell line.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11