4-methylthioamphetamine-induced hyperthermia in mice: influence of serotonergic and catecholaminergic pathways

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Carmo, H (Author) FFUP; Remiao, F (Author) FFUP; Carvalho, F (Author) FFUP; Fernandes, E (Author) FFUP; de Boer, D (Author) Other; dos Reys, LA (Author) Other; Bastos, MD (Author) FFUP

Journal

Title: Toxicology and Applied Pharmacology

Vol. 190

Pages: 262-271

ISSN: 0041-008X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 17 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-FSZ

DOI: 10.1016/s0041-008x(03)00190-x

Abstract (EN): 4-Methylthioamphetamine (4-MTA), also known as p-methylthioamphetamine, is a new amphetamine derivative which in humans has been increasingly associated with severe intoxications and several deaths. As hyperthermia is considered to be one of the most life-threatening acute physiological consequences of amphetamine-related intoxications, it was our aim to determine whether 4-MTA induces changes in body temperature in a mouse model. Accordingly, we measured the subcutaneous temperature after acute administration of 4-MTA in CD1 mice. Because hyperthermia seems to result from the central and peripheral actions of catecholamines and serotonin (5-hydroxytriptamine or 5-HT), we also investigated the possible interactions of some catecholaminergic and serotonergic receptor blockers and the inhibition of monoamine oxidase (MAO) with this effect. 4-MTA induced hyperthermia in CD1 mice. Blockade of the 5-HT receptors with methysergide and MAO inhibition with pargyline resulted in the potentiation of the 4-MTA-induced hyperthermic effect. Blockade of the alpha(1)-adrenergic receptors with prazosin completely reverted the 4-MTA-induced hyperthermia while with the beta-adrenergic receptor blocker dl-propranolol this reversal was not complete. Blockade of the alpha(1)-adrenergic receptors with yohimbine had no effect on the hyperthermia induced by 4-MTA. These results suggest that 4-MTA-induced hyperthermia is highly influenced by the catecholaminergic and serotonergic receptor activation and the MAO activity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10