Antioxidant enzyme activity in mesenteric artery from DPSPX-Hypertensive rats

• Type: Article in International Conference Proceedings Book
• Date: 2002

Authors

Sousa, T (Author) Other; Fernandes, E (Author) FFUP; Morato, M (Author) FFUP; Carvalho, F (Author) FFUP; Albino Teixeira, A (Author) FMUP

Conference proceedings International

Title: 22ND MEETING OF THE EUROPEAN SOCIETY FOR MICROCIRCULATION: MICROCIRCULATION AND VASCULAR BIOLOGY

Pages: 267-270

22nd Meeting of the European-Society-for-Microcirculation

EXETER, ENGLAND, AUG 28-30, 2002

Indexing

ISI Web of Knowledge - 0 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-S9Y

Abstract (EN): DPSPX (1,3-dipropyl-8-sulfophenylxanthine) induces hypertension, vascular hypertrophy and hyperplasia and impaired endothelium dependent vasodilation. Since oxidative stress is linked with cardiovascular injury we aimed at evaluating if DPSPX induced-hypertension is accompanied by vascular modifications in enzymatic antioxidant defenses. Three groups of rats were evaluated: control, treated with DPSPX (90 mg.kg(-1).h(-1), i.p.) for 3 days and sacrificed on day 3; and treated with DPSPX (90 mg.kg(-1),h(-1), i.p.) for 7 days and sacrificed on day 15. DPSPX treatment for 3 days increased the activity of glutathione peroxidase, glutathione reductase and glutathione-S-transferase. We can conclude that DPSPX-induced hypertension is associated with an increase of the mesenteric artery enzymatic antioxidant defenses in the acute phase of hypertension.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4