Electrochemical determination of dihydrocodeine in pharmaceuticals

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Garrido, JMPJ (Author) Other; Delerue Matos, C (Author) Other; Borges, F (Author) FFUP; Macedo, TRA (Author) Other; Oliveira Brett, AM (Author) Other

Journal

Title: Analytical Letters

Vol. 36

ISSN: 0003-2719

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 4 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-000-J4V

Abstract (EN): Two analytical methods for the quality control of dihydrocodeine in commercial pharmaceutical formulations have been developed and compared with reference methods: a square wave voltammetric (SWV) method and a flow injection analysis system with electrochemical detection (FIA-EC). The electrochemical methods proposed were successfully applied to the determination of dihydrocodeine in pharmaceutical tablets and in oral solutions. These methods do not require any pretreatment of the samples, the formulation only being dissolved in a suitable electrolyte. Validation of the methods showed it to be precise, accurate and linear over the concentration range of analysis. The automatic procedure based on a flow injection analysis manifold allows a sampling rate of 115 determinations per hour.

Language: English

Type (Professor's evaluation): Scientific