Antioxidant versus cytotoxic properties of hydroxycinnamic acid derivatives - A new paradigm in phenolic research

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Mario Esteves (Author) Other; Christophe Siquet (Author) FEUP; Alexandra Gaspar (Author) Other; Vitor Rio (Author) Other; Joana B Sousa (Author) Other; Salette Reis (Author) FFUP; Maria P M Marques (Author) Other; Fernanda Borges (Author) FFUP

Journal

Title: Archiv der Pharmazie

Vol. 341 No. 3

Pages: 164-173

ISSN: 0365-6233

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 46 Citations

Scopus - 48 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-004-0ZW

DOI: 10.1002/ardp.200700168

Abstract (EN): Trihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human cervix adenocarcinoma cell line (Hel,a). The partition coefficients presently obtained for the trihydroxycinnamic derivatives correlate well both with their structural characteristics and with their antioxidant/cytotoxic activities. A positive structure-activity-property relationship between cytotoxic and antioxidant activities, which is intrinsically related with physico-chemical and conformational properties, is anticipated, as a noteworthy study that must be done for phenolic systems. As damage events are frequently correlated with oxidative stress, the prevalence of both properties in a single compound could be beneficial in terms of rationale preventive or therapeutic purposes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10