Cytotoxic and COX-2 inhibition properties of hydroxycinnamic derivatives

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Marques, MPM (Author) Other; Borges, F (Author) FFUP; Sousa, J (Author) Other; Calheiros, R (Author) Other; Garrido, J (Author) Other; Gaspar, A (Author) Other; Antunes, F (Author) Other; Diniz, C (Author) FFUP; Fresco, P (Author) FFUP

Journal

Title: Letters in Drug Design and Discovery

Vol. 3

Pages: 316-320

ISSN: 1570-1808

Publisher: Bentham Science

Indexing

ISI Proceedings

ISI Web of Knowledge - 13 Citations

Scopus - 12 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-004-JYW

DOI: 10.2174/157018006777574212

Abstract (EN): The anticancer (cytotoxicity against human mammary gland adenocarcinoma cells) and anti-inflammatory properties (COX-2 inhibition) of the hydroxycinnamic derivatives trans-3-(3,4,5-trihydroxyphenyl)-2-propenoic acid, trans-ethyl(3,4,5-trihydroxyphenyl)-2-propenoate and diethyl 2-(3,4,5-trihydroxy-phenylmethylene)malonate were screened. Data point out a putative correlation between anti-inflammatory and anticancer properties and suggest hydroxycinnamic derivatives as promising lead compounds for the development of anti-inflammatory/chemopreventive agents.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5