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Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles

Title
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
Type
Article in International Scientific Journal
Year
1998
Authors
de Castro, B
(Author)
FCUP
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Gameiro, P
(Author)
FCUP
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Guimaraes, C
(Author)
Other
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Lima, JLFC
(Author)
FFUP
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Reis, S
(Author)
FFUP
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Journal
Vol. 18
Pages: 573-577
ISSN: 0731-7085
Publisher: Elsevier
Scientific classification
FOS: Natural sciences > Chemical sciences
Other information
Authenticus ID: P-001-6NN
Abstract (EN): The effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two beta-blockers (atenolol and nadolol) were studied at 25.0 +/- 0.1 degrees C and I = 0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the beta-blockers.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 5
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