Nutritional regulation of hepatic glucose metabolism in fish

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Enes, P (Author) FCUP; Panserat, S (Author) Other; Kaushik, S (Author) Other; Oliva Teles, A (Author) FCUP

Journal

Title: Fish Physiology and Biochemistry

Vol. 35

Pages: 519-539

ISSN: 0920-1742

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 404 Citations

Scopus - 425 Citations

Scientific classification

FOS: Agrarian Sciences > Agriculture, Forestry, and Fisheries

Other information

Authenticus ID: P-003-H02

DOI: 10.1007/s10695-008-9259-5

Abstract (EN): Glucose plays a key role as energy source in the majority of mammals, but its importance in fish appears limited. Until now, the physiological basis for such apparent glucose intolerance in fish has not been fully understood. A distinct regulation of hepatic glucose utilization (glycolysis) and production (gluconeogenesis) may be advanced to explain the relative inability of fish to efficiently utilize dietary glucose. We summarize here information regarding the nutritional regulation of key enzymes involved in glycolysis (hexokinases, 6-phosphofructo-1-kinase and pyruvate kinase) and gluconeogenesis (phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and glucose-6-phosphatase) pathways as well as that of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. The effect of dietary carbohydrate level and source on the activities and gene expression of the mentioned key enzymes is also discussed. Overall, data strongly suggest that the liver of most fish species is apparently capable of regulating glucose storage. The persistent high level of endogenous glucose production independent of carbohydrate intake level may lead to a putative competition between exogenous (dietary) glucose and endogenous glucose as the source of energy, which may explain the poor dietary carbohydrate utilization in fish.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 21