On complex I and other NADH : Ubiquinone reductases of Neurospora crassa mitochondria

• Type: Article in International Scientific Journal
• Date: 2001

Authors

videira, a (Author) ICBAS; duarte, m (Author) ICBAS

Journal

Title: Journal of Bioenergetics and Biomembranes

Vol. 33

Pages: 197-203

ISSN: 0145-479X

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 31 Citations

Scopus - 31 Citations

Other information

Authenticus ID: P-000-VC7

DOI: 10.1023/A:1010778802236

Abstract (EN): The mitochondrial complex I is the first component of the respiratory chain coupling electron transfer from NADH to ubiquinone to proton translocation across the inner membrane of the organelle. The enzyme from the fungus Neurospora crassa is similar to that of other organisms in terms of protein and prosthetic group composition, structure, and function. It contains a high number of polypeptide subunits of dual genetic origin. Most of its subunits were cloned, including those binding redox groups. Extensive gene disruption experiments were conducted, revealing many aspects of the structure, function, and biogenesis of complex I. Complex I is essential for the sexual phase of the life cycle of N. crassa, but not for the asexual stage. In addition to complex I, the fungal mitochondria contain at least three nonproton-pumping alternative NAD(P)H dehydrogenases feeding electrons to the respiratory chain from either matrix or cytosolic substrates.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7