Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation

• Type: Article in International Scientific Journal
• Date: 2001

Authors

Leal, IS (Author) Other; Smedegard, B (Author) Other; Andersen, P (Author) Other; Appelberg, R (Author) ICBAS

Journal

Title: Immunology

Vol. 104

Pages: 157-161

ISSN: 0019-2805

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 45 Citations

Scopus - 46 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences > Medical sciences > Medicine > Infections

Other information

Authenticus ID: P-000-T4S

DOI: 10.1046/j.1365-2567.2001.01305.x

Abstract (EN): We evaluated the use of recombinant human interleukin-6 (rhIL-6) and a monoclonal antibody specific for interferon-gamma (IFN-gamma) as co-adjuvants in a subunit vaccine against tuberculosis consisting of the culture filtrate proteins of Mycobacterium tuberculosis (ST-CF) emulsified in the adjuvant dimethyl-dioctadecylammonium bromide (DDA). Both the addition of rhIL-6 and the neutralization of IFN-gamma resulted in an increased T helper type 1 (Th1) response characterized by enhanced IFN-gamma production and cell proliferation. Nevertheless, this did not result in the enhancement of protection against either an intravenous or an aerosol M. tuberculosis challenge. Our data stress the need to identify further correlates of protection in addition to IFN-gamma production to screen vaccines against tuberculosis infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5