Clinical significance of brain natriuretic peptide in patients with postmyocardial infarction

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Bettencourt, P (Author) FMUP; Ferreira, A (Author) Other; Pardal Oliveira, N (Author) Other; Pereira, M (Author) Other; Queiros, C (Author) Other; Araujo, V (Author) Other; Cerqueira Gomes, M (Author) Other; Maciel, MJ (Author) FMUP

Journal

Title: Clinical Cardiology

Vol. 23 No. 12

Pages: 921-927

ISSN: 0160-9289

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 26 Citations

ISI Web of Science

Scopus - 37 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-Y86

Abstract (EN): Background: Risk stratification after acute myocardial infarction (AMI) includes the evaluation of left ventricular (LV) function. Natriuretic peptides, and particularly brain natriuretic peptide (BNP), emerged as a potential marker of ventricular function and prognosis after AMI. Hypothesis: Brain natriuretic peptide levels are related to ventricular function, either systolic or isolated diastolic, and can give prognostic information in patients surviving AMI. Methods: In all, 101 patients were enrolled. An echocardiographic (M-mode, two-dimensional, and pulsed Doppler) evaluation was performed and blood samples for BNP measurement were obtained, Clinical events were recorded during 12 month?, of follow-up. Results: A negative correlation between BNP and LV ejection fraction was observed (r = -0.38; p < 0.001). The BNP levels were higher among patients with LV systolic dysfunction than in patients; with isolated diastolic dysfunction (339.1 +/- 249.9 vs. 168.0 +/- 110.5 pg/ml, p = 0.001), The latter had higher levels of BNP than those with normal LV function (68.3 +/- 72.6 pg/ml, p < 0.001). The BNP accuracy to detect LV systolic dysfunction was good (area under the ROC curve [AUC] = 0.83) and increased when isolated diastolic dysfunction was also considered (AUC = 0.87. Brain natriuretic peptide had a very good accuracy in the prediction of death (AUC = 0.95) and the development of heart failure (AUC = 0.90), Conclusion: These results extend previous evidence relating BNP to systolic function after AMI. Furthermore. a relationship between BNP levels and diastolic function was found. Brain natriuretic peptide had a very good performance in detecting the occurrence of an adverse event. We conclude that BNP can detect high-risk patients and help select patients for more aggressive approaches.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7