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Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles

Title
Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles
Type
Article in International Scientific Journal
Year
2009
Authors
Schmitt F
(Author)
FMUP
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Journal
Title: HistopathologyImported from Authenticus Search for Journal Publications
Vol. 55 No. 4
Pages: 594-599
ISSN: 0309-0167
Publisher: Wiley-Blackwell
Scientific classification
FOS: Medical and Health sciences > Other medical sciences
Other information
Authenticus ID: P-003-EN4
Abstract (EN): Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles Aims: To evaluate the relationship between microvessel density assessed by endoglin expression and the molecular subtypes of human invasive breast carcinomas and whether there is evidence to indicate that angiogenesis could be a putative target for therapy in specific subsets of breast cancer. Methods and results: We studied a series of 161 breast carcinomas, but information was available on only 142 tumours. We correlated endoglin expression with distinct breast carcinoma subgroups classified according to immunohistochemical profiling. Additionally, we compared it with other biomarkers for the aggressive basal-like subset and with available histopathological data. Although the basal-like subtype has higher microvessel density, there are no significant differences with the other molecular subtypes of breast cancer. Conclusions: This study found no significant differences in tumour vascularity in different molecular subtypes of breast cancer.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 6
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