Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Moura LM (Author) Other; Ramos, SF (Author) Other; Zamorano, JL (Author) Other; Barros, IM (Author) Other; Azevedo L (Author) FMUP; Rocha Goncalves, F (Author) Other; Rajamannan, NM (Author) Other

Journal

Title: Journal of the American College of Cardiology

Vol. 49

Pages: 554-561

ISSN: 0735-1097

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 292 Citations

Scopus - 347 Citations

Other information

Authenticus ID: P-004-BVB

DOI: 10.1016/j.jacc.2006.07.072

Abstract (EN): Objectives The objective of this study was to test the effect of a 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitor on the progression of moderate to severe aortic stenosis as measured by echocardiography. Background Recent retrospective studies support the hypothesis that statins slow the progression of aortic stenosis. Methods We performed an open-label, prospective study evaluating 121 consecutive patients with asymptomatic moderate to severe aortic stenosis (aortic valve area >= 1.0 cm(2); mean age 73.7 +/- 8.9 years; 57 men and 64 women), treated with and without rosuvastatin according to the National Cholesterol Education Program Adult Treatment Panel III guidelines. Echocardiographic, serum lipid, and inflammatory markers were measured at baseline and every 6 months for IS months. Results Sixty-one patients (50.4%) with elevated LDL (159.7 +/- 33.4 mg/dl), aortic valve velocity (3.65 +/- 0.64 m/s), and aortic valve area (1.23 +/- 0.42 cm(2)) received rosuvastatin (20 mg/day), and 60 (49.6%) with a normal LDL (118.6 +/- 37.4 mg/dl), aortic valve velocity (3.62 +/- 0.61 m/s), and aortic valve area (1.20 +/- 0.35 cm(2)) received no statin. During a mean follow-up of 73 +/- 24 weeks, the change in aortic valve area in the control group was -0.10 +/- 0.09 cm(2)/year versus -0.05 +/- 0.12 cm(2)/year in the rosuvastatin group (p = 0.041). The increase in aortic valve velocity was 0.24 +/- 0.30 m/s/year in the control group and 0.04 +/- 0.38 m/s/year in the rosuvastatin group (p = 0.007). There was significant improvement in serum lipid and echocardiographic measures of aortic stenosis in the statin group. Conclusions Prospective treatment of aortic stenosis with rosuvastatin by targeting serum LDL slowed the hemodynamic progression of aortic stenosis. This is the first prospective study that shows a positive effect of statin therapy for this disease process.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8