Go to:
Logótipo
Você está em: Start > Publications > View > Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components
Map of Premises
Principal
Publication

Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components

Title
Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components
Type
Article in International Scientific Journal
Year
2009
Authors
Schmitt F
(Author)
FMUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Journal
Title: Journal of PathologyImported from Authenticus Search for Journal Publications
Vol. 218
Pages: 301-315
ISSN: 0022-3417
Publisher: Wiley-Blackwell
Scientific classification
FOS: Medical and Health sciences > Other medical sciences
Other information
Authenticus ID: P-003-HXN
Abstract (EN): Micropapillary carcinomas (MPCs) can present as a rare histological special type of breast cancer; however, this histological type is more frequently found admixed with invasive ductal carcinomas of no special type (IDC-NSTs). We have previously demonstrated that pure MPCs constitute a distinct entity at the morphological and genetic levels. Here, we sought to determine whether mixed MPCs have genomic aberrations similar to those found in pure MPCs, and to investigate whether the distinct morphological components of MPCs harbour different genetic aberrations. Using high-resolution microarray comparative genomic hybridization (aCGH), we profiled a series of 10 MPCs of mixed histology and 20 IDC-NSTs matched for grade and oestrogen receptor (ER) status. In addition, we generated tissue microarrays containing a series of 24 pure and 40 mixed MPCs and performed immunohistochemical analysis with ER, progesterone receptor (PR), Ki-67, HER2, cytokeratin (CK) 5/6, CK14, CK17, EGFR, topoisomerase-II alpha, cyclin D1, caveolin-1 and E-cadherin antibodies. In situ hybridization was employed to evaluate the prevalence of HER2, TOP2A, EGFR, CCND1, MYC and FGFR1 gene amplification. Our results demonstrate that mixed MPCs harbour similar patterns of genomic aberrations and phenotype (82.5% luminal and 17.5% HER2) compared to pure MPCs. A comparison between the distinct morphological components of mixed MPCs in a pairwise fashion revealed that both components harbour strikingly similar genomic profiles. When compared to grade- and ER-matched IDC-NSTs, mixed MPCs significantly more frequently harboured amplification of multiple regions on 8q (adjusted Fisher's p value <0.05). Furthermore, mixed MPCs displayed higher proliferative rates than grade- and ER-matched IDC-NST.s. Our results suggest that micropapillary differentiation in breast cancer may identify a subgroup of more aggressive ER-positive breast carcinomas, even in those featuring a mixed histology, and that mixed MPCs are more closely related to pure MPCs than to IDC-NSTs. Copyright (C) 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 15
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same authors

2023 European Thyroid Association Clinical Practice Guidelines for thyroid nodule management (2023)
Another Publication in an International Scientific Journal
Durante, C; Hegedues, L; Czarniecka, A; Paschke, R; Russ, G; Fernando Schmitt; Soares, P; Solymosi, T; Papini, E
XRCC1 Arg399Gln and RAD51 5 ' UTR G135C polymorphisms and their outcome in tumor aggressiveness and survival of Portuguese breast cancer patients (2008)
Another Publication in an International Scientific Journal
Sandra Costa; Daniela Pinto; Deolinda Pereira; Helena Rodrigues; Jorge Cameselle Teijeiro; Rui Medeiros; Fernando Schmitt
When Morphology Meets Somatic Mutations: The New Possible Scenario in Thyroid Fine-Needle Aspiration (2016)
Another Publication in an International Scientific Journal
Rossi, ED; Fernando Schmitt
Vitamin D and the mammary gland: a review on its role in normal development and breast cancer (2012)
Another Publication in an International Scientific Journal
Lopes, N; Joana Paredes; Costa, JL; Ylstra, B; Fernando Schmitt

See all (691)

Of the same journal

Relationship between the expression of p53 and the aggressiveness of gastric carcinoma (1997)
Another Publication in an International Scientific Journal
Seruca, R; David L; Sobrinho Simoes, M
Re. 'Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways' (2001)
Another Publication in an International Scientific Journal
Nabais, S; Carneiro F; Nogueira, AMMF; Machado JC; Seruca, R; Sobrinho Simoes, M
Mitochondrial DNA 'common' deletion in Hurthle cell lesions of the thyroid (2000)
Another Publication in an International Scientific Journal
Maximo, V; Sobrinho Simoes, M
Maspin is expressed in the nuclei of breast myoepithelial cells (2002)
Another Publication in an International Scientific Journal
Reis, JS; Milanezi, F; Fernando Schmitt
E-cadherin mutations in gastric carcinoma (2000)
Another Publication in an International Scientific Journal
Machado JC; Carneiro F; Sobrinho Simoes, M; Endoh, Y; Tamura, G; Watanabe, H; Motoyama, T

See all (39)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Medicina Dentária da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-23 at 21:28:44 | Privacy Policy | Personal Data Protection Policy | Whistleblowing | Electronic Yellow Book