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Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis

Title
Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis
Type
Article in International Scientific Journal
Year
2008
Authors
Fernando Schmitt
(Author)
FMUP
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Journal
Vol. 59
Pages: 425-430
ISSN: 0940-2993
Indexing
Scientific classification
FOS: Medical and Health sciences > Basic medicine
CORDIS: Health sciences > Medical sciences > Medicine > Pathological anatomy
Other information
Authenticus ID: P-004-0E6
Abstract (EN): Aim: Acrolein (ACR) is a urinary metabolite of cyclophosphamide (CPS) and ifosfamide (IFS), which has been demonstrated to be the causative agent of hemorrhagic cystitis (HQ, induced by these compounds. In this study, we investigate the participation of cyclooxygenase-2 (COX-2) on ACR-induced HC. Methods: Male Wistar rats (150-200 g; six rats per group) were treated with distilled water or intravesical ACR and analyzed by changes in bladder wet weight, macroscopic and microscopic parameters and COX-2 expression. Results: COX-2 immunohistochemical expression was significant 12h after ACR administration mainly in subepithelial cells. ACR injection also alters some macroscopic and microscopic parameters in bladder of rats analyzed by Gray's criteria. Conclusions: COX-2 participates in the pathogenesis of ACR-induced HC first seen 12 h after initial contact between ACR and urothelium.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 6
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