N-terminal-pro-B type natriuretic peptide as a useful tool to evaluate pulmonary hypertension and cardiac function in CDH infants

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Baptista MJ (Author) Other; Rocha G (Author) Other; Clemente F (Author) Other; Azevedo L (Author) FMUP; Tibboel D (Author) Other; Leite-Moreira AF (Author) FMUP; Guimarães H (Author) FMUP; Areias JC (Author) Other; Correia-Pinto J (Author) Other

Journal

Title: Neonatology

Vol. 94 No. 1

Pages: 22-30

ISSN: 1661-7800

Publisher: Karger

Indexing

ISI Web of Knowledge - 36 Citations

Scopus - 39 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-004-47H

DOI: 10.1159/000112641

Abstract (EN): Objective: In congenital diaphragmatic hernia (CDH) the severity of pulmonary hypertension (PH) is considered, by several authors, determinant of clinical outcome. Plasmatic N-terminal-pro- B type natriuretic peptide (NT-proBNP) might be useful in diagnosis and management of PH in newborns, although its interest in CDH infants remains to be defined. Early NT-proBNP levels were assessed in CDH infants and correlated with cardiovascular echocardiographic parameters. Patients and Methods: 28 newborns, CDH and age-matched controls were enrolled in a prospective study. Clinical condition, NT-proBNP plasmatic levels, echo parameters of PH and biventricular function were assessed at 24 h after delivery as well as survival outcome. Results: Estimated mean pulmonary pressure and NT-proBNP were significantly higher in CDH than control infants. NT-proBNP significantly correlated with estimated pulmonary artery pressure, right ventricular Tei index, and tricuspid E/A ratio. Additionally, we found that CDH infants with NT-proBNP >11,500 pg/ml experienced a worse prognosis. Conclusions: We demonstrated that PH is associated with NT-proBNP elevation and diastolic impairment in CDH infants. Early elevations in NT-proBNP levels seem to alert for a subset of CDH infants with worse prognosis. Copyright (C) 2007 S. Karger AG, Basel.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9