DIFFERENTIAL ACTIVATION OF C-FOS IN SPINAL NEURONS BY DISTINCT CLASSES OF NOXIOUS STIMULI

• Type: Article in International Scientific Journal
• Date: 1993

Authors

Deolinda Lima (Author) FMUP; António Avelino Silva (Author) FMUP; COIMBRA, A (Author) Other

Journal

Title: NeuroReport

Vol. 4

Pages: 747-750

ISSN: 0959-4965

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 67 Citations

Scopus - 70 Citations

Other information

Authenticus ID: P-001-N0W

DOI: 10.1097/00001756-199306000-00037

Abstract (EN): THE laminar distribution of spinal cord neurones expressing immunoreactivity to the Fos protein was evaluated in the rat following chemical, thermal or mechanical noxious stimulation of the skin for 2 h. After stimulation by 20% or 5% formalin, Fos-immunoreactive neurones prevailed in lamina I where they accounted for 64% and 59%, respectively, of the entire population of Fos-immunoreactive spinal cells. Values in the remaining laminae were low (2-10%). Following thermal stimulation by radiant heat at 65-degrees-C or 58-degrees-C, Fos cells were concentrated in laminae I and IIo, amounting to 57% and 62%, respectively, in lamina I, and to 26% and 29% in lamina IIo. Values were lower than 10% in the remaining laminae. Following mechanical stimulation by pinching or needle prick, Fos-positive cells were regularly distributed throughout laminae I-V amounting to 25-26% in lamina I, and 10-20% in each of the remaining laminae. These findings suggest that the spinal neuronal groups called upon by prolonged noxious stimulation differ according to the nature of the stimulus.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4