COGNITIVE IMPAIRMENT OF PREFRONTAL-DEPENDENT DECISION-MAKING IN RATS AFTER THE ONSET OF CHRONIC PAIN

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Pais Vieira, M (Author) Other; Mendes Pinto, MM (Author) Other; Lima, D (Author) FMUP; Galhardo, V (Author) FMUP

Journal

Title: Neuroscience

Vol. 161

Pages: 671-679

ISSN: 0306-4522

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 82 Citations

ISI Web of Science

Scopus - 85 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences ; Health sciences > Neuroscience > Neurobiology

Other information

Authenticus ID: P-003-HHJ

DOI: 10.1016/j.neuroscience.2009.04.011

Abstract (EN): Forced choice between alternative options of unpredictable outcome is a complex task that requires continual update of the value associated with each option. Prefrontal areas such as the orbitofrontal cortex (OFC) have been shown to play a major role in performance on ambiguous decision-making tasks with substantial risk component, broadly named as "gambling tasks." We have recently demonstrated that rats display complex decision-making behavior in a rodent gambling task based on serial choices between rewards of different value and probability. This rodent task retains many of the key characteristics of the human Iowa Gambling Task (IGT), and performance in this novel task is also disrupted by OFC or amygdalar lesioning. In the present study we addressed if rat models of chronic pain would have impaired performance in this gambling task, since it is already known that the IGT response patterns of human pain patients are comparable to individuals with OFC lesions. We found that animals with a monoarthritic inflammatory model of chronic pain systematically preferred the lever associated with larger but infrequent rewards. In addition, we measured the neurochemical content of the OFC, amygdala and nucleus accumbens using HPLC, and found that in prolonged chronic pain animals there was a decrease in the tonic levels of dopamine, DOPAC (3,4-hydroxyphenylacetic acid) and 5-HIAA (5-hydroxyindole-3-acetic acid) in the OFC. This is the first report of the effect of chronic pain in rat decision-making processes and supports the notion that pain may have profound effects on the functioning of the reward-aversion circuitry relevant to strategic planning.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9