Aging increases oxidative stress and renal expression of oxidant and antioxidant enzymes that are associated with an increased trend in systolic blood pressure

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Pedro Gomes (Author) FMUP; Sónia Simão (Author) FMUP; Elisabete Silva (Author) FMUP; Vanda Pinto (Author) FMUP; João Amaral (Author) Other; Joana Afonso (Author) Other; Maria Paula Serrão (Author) FMUP; Maria João Pinho (Author) FMUP; Patrício Soares da Silva (Author) FMUP

Journal

Title: Oxidative Medicine and Cellular Longevity

Vol. 2 No. 3

Pages: 138-145

ISSN: 1942-0900

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 44 Citations

Scopus - 43 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-J0B

Abstract (EN): The aim of this study was to investigate whether the effects of aging on oxidative stress markers and expression of major oxidant and antioxidant enzymes associate with impairment of renal function and increases in blood pressure. To explore this, we determined age-associated changes in lipid peroxidation (urinary malondialdehyde), plasma and urinary hydrogen peroxide (H(2)O(2)) levels, as well as renal H(2)O(2) production, and the expression of oxidant and antioxidant enzymes in young (13 weeks) and old (52 weeks) male Wistar Kyoto (WKY) rats. Urinary lipid peroxidation levels and H(2)O(2) production by the renal cortex and medulla of old rats were higher than their young counterparts. This was accompanied by overexpression of NADPH oxidase components Nox4 and p22(phox) in the renal cortex of old rats. Similarly, expression of superoxide dismutase (SOD) isoforms 2 and 3 and catalase were increased in the renal cortex from old rats. Renal function parameters (creatinine clearance and fractional excretion of sodium), diastolic blood pressure and heart rate were not affected by aging, although slight increases in systolic blood pressure were observed during this 52-week period. It is concluded that overexpression of renal Nox4 and p22(phox) and the increases in renal H(2)O(2) levels in aged WKY does not associate with renal functional impairment or marked increases in blood pressure. It is hypothesized that lack of oxidative stress-associated effects in aged WKY rats may result from increases in antioxidant defenses that counteract the damaging effects of H(2)O(2).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8