Cardiac remodeling and dysfunction in nephrotic syndrome.

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Mónica Moreira-Rodrigues (Author) ICBAS; Roncon-Albuquerque R Jr (Author) FEUP; Tiago Henriques-Coelho (Author) FMDUP; André Lourenço (Author) FMDUP; Benedita Sampaio-Maia (Author) FMDUP; Santos, J (Author) Other; Pestana M (Author) FMUP; Leite-Moreira A (Author) FMDUP

Journal

Title: Kidney International

Vol. 71 No. 12

Pages: 1240-1248

ISSN: 0085-2538

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 19 Citations

ISI Web of Science

Scopus - 18 Citations

Pubmed / Medline

Scientific classification

FOS: Natural sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-9W3

Abstract (EN): There is an increased incidence of heart disease in patients with chronic nephrotic syndrome (NS), which may be attributable to the malnutrition and activated inflammatory state accompanying the sustained proteinuria. In this study, we evaluated renal function, cardiac morphometry, contractile function, and myocardial gene expression in the established puromycin aminonucleoside nephrosis rat model of NS. Two weeks after aminonucleoside injection, there was massive proteinuria, decreased creatinine clearance, and a negative sodium balance. Skeletal and cardiac muscle atrophy was present and was accompanied by impaired left ventricular (LV) hemodynamic function along with decreased contractile properties of isolated LV muscle strips. The expression of selected cytokines and proteins involved in calcium handling in myocardial tissue was evaluated by real time polymerase chain reaction. This revealed that the expression of interleukin-1beta, tumor necrosis factor-alpha, and phospholamban were elevated, whereas that of cardiac sarco(endo)plasmic reticulum calcium pump protein was decreased. We suggest that protein wasting and systemic inflammatory activation during NS contribute to cardiac remodeling and dysfunction.

Language: English

Type (Professor's evaluation): Scientific