IN-VIVO EFFECTS OF THE MONOAMINE-OXIDASE INHIBITORS RO-41-1049 AND RO-19-6327 ON THE PRODUCTION AND FATE OF RENAL DOPAMINE

• Type: Article in International Scientific Journal
• Date: 1994

Authors

Vieira-Coelho MA (Author) Other; Fernandes MH (Author) FMDUP; Soares-da-Silva P (Author) Other

Journal

Title: Journal of Neural Transmission, Supplement

Pages: 365-370

ISSN: 0303-6995

Publisher: Springer

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 11 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-001-KVW

Abstract (EN): Ro 41-1049 (2 mg/kg), but not Ro 19-6327 (2 mg/kg), was found to reduce (70% to 93% decrease) DOPAC tissue levels in the renal cortex, outer and inner medulla and, to a similar extent, DOPAC concentrations in plasma. This inhibitory effect was, however, not accompained by an increased accumulation of newly-formed dopamine. The results presented show that type A monoamine oxidase is the predominant form of the enzyme involved in the metabolism of renal dopamine and some of the amine which escapes deamination might leave the kidney through the renal vein in the intact from.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6