Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression

• Type: Article in International Scientific Journal
• Date: 2025

Authors

Martinez-Ciarpaglini, C (Author) Other; Barros, R (Author) Other; Caballero, C (Author) Other; Boggino, H (Author) Other; Alarcón-Molero, L (Author) Other; peleteiro, b (Author) FMUP; Ruiz-García, E (Author) Other; Fernandez-Figueroa, E (Author) Other; Herrera-Goepfert, R (Author) Other; Díaz-Romero, C (Author) Other; Ferreira, R (Author) Other; Groen-van Schooten, TS (Author) Other; Gauna, C (Author) Other; Pereira, R (Author) Other; Cantero, D (Author) Other; Lezcano, H (Author) Other; Esteso, F (Author) Other; O'Connor, J (Author) Other; Riquelme, A (Author) Other; Owen, GI (Author) Other; Garrido, M (Author) Other; Roa, JC (Author) Other; Ruiz-Pace, F (Author) Other; Vivancos, A (Author) Other; Diez-García, M (Author) Other; Alsina, M (Author) Other; Matito, J (Author) Other; Martin, A (Author) Other; Gómez, M (Author) Other; Castillo, E (Author) Other; Vila, M (Author) Other; Santos-Antunes, J (Author) Other; Costa, A (Author) Other; Lordick, F (Author) Other; Farres, J (Author) Other; Palomar-De Lucas, B (Author) Other; Cabeza-Segura, M (Author) Other; Villagrasa, R (Author) Other; Jimenez-Martí, E (Author) Other; Miralles-Marco, A (Author) Other; Dienstmann, R (Author) Other; Derks, S (Author) Other; Figueiredo C (Author) FMUP; Cervantes, A (Author) Other; Carneiro, F (Author) Other; Fleitas-Kanonnikoff, T (Author) Other

Journal

Title: Gastric Cancer

Vol. 28

Pages: 160-173

ISSN: 1436-3291

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-017-WHW

DOI: 10.1007/s10120-024-01578-3

Abstract (EN): IntroductionGastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries.Material and methodsTreatment-na & iuml;ve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries. Formalin-fixed paraffin-embedded primary tumour endoscopic biopsy samples were collected and submitted for central morphological and immunohistochemical characterization and TP53 molecular assessment and Helicobacter pylori infection.ResultsA total of 259 patients were included in the study: 137 (53%) from LATAM and 122 (47%) from Europe. Significant biological differences were detected between European and LATAM patients. Low representation of chromosomal instability (CIN) and HER2 positive cases were found in LATAM. MUC6 and PD-L1 were more frequently overexpressed in European cases, showing a significant correlation across the entire study population, with this association being especially pronounced in MMRdeficient cases. Both TP53 mutation by next-generation sequencing and p53 immunohistochemical aberrant pattern were linked with features associated with chromosomal instability. No regional differences were observed in H. pylori prevalence or abundance, indicating that the afore mentioned variations cannot be attributed to this factor.ConclusionOur findings underscore a need for region-specific approaches in gastroesophageal cancer diagnosis and treatment. MUC6 emerges as a putative immune regulator that needs further investigation. Research tailored to the unique biological profiles in different global regions is crucial to effectively address the observed disparities.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14