Group B Streptococcus rectovaginal colonization screening on term pregnancies: culture or polymerase chain reaction?

• Type: Article in International Scientific Journal
• Date: 2023

Authors

Costa, SC (Author) Other; Machado, AP (Author) Other; Teixeira, C (Author) Other; Cerqueira, L (Author) Other; Rodrigues, T (Author) Other; Ribeiro, M (Author) Other; Moucho, M (Author) Other

Journal

Title: Journal of Maternal-Fetal and Neonatal Medicine

Vol. 36

ISSN: 1476-7058

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Z-49K

DOI: 10.1080/14767058.2023.2262078

Abstract (EN): Objectives: The aim of this study was to evaluate if screening Group B Streptococcus colonization by intrapartum polymerase chain reaction could improve intrapartum administration of antibiotic prophylaxis, compared with antepartum culture screening and analyze the sensitivity and specificity of polymerase chain reaction test.Methods: 198 pregnant women with Group B Streptococcus colonization antepartum culture screening were included. When they arrived at hospital for delivery, two rectovaginal swabs were collected: for culture and polymerase chain reaction method.Results: The rate of Group B Streptococcus colonization antepartum detected by culture was 16.7%; at delivery was 17.2% when detected by culture and 19.7% using polymerase chain reaction method. The rate of inconclusive polymerase chain reaction tests was 0.5%. Considering intrapartum culture screening as gold standard, sensitivity and specificity of polymerase chain reaction test for intrapartum Group B Streptococcus colonization was 97.1% and 95.7%, respectively. The global rate of discordance between antepartum and intrapartum Group B Streptococcus colonization was 6.6%. The rate of women not treated with intrapartum antibiotic prophylaxis in the setting of positive intrapartum culture was significantly lower using intrapartum polymerase chain reaction test (0.5%) than with antepartum culture method (3.5%, p = 0.035).Conclusion: The use of intrapartum antibiotic prophylaxis can be more efficient when screening Group B Streptococcus colonization intrapartum by polymerase chain reaction test. Polymerase chain reaction method had a good performance in our study, with high sensitivity and specificity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7