Biopesticide spinosad: Unraveling ecotoxicological effects on zebrafish, Danio rerio

• Type: Article in International Scientific Journal
• Date: 2024

Authors

Amaral, I (Author) Other; Antunes, SC (Author) FCUP; Rebelo, D (Author) Other; Carvalho, AP (Author) FCUP; Rodrigues, S (Author) Other

Journal

Title: Environmental Toxicology and Pharmacology

Vol. 108

ISSN: 1382-6689

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-010-D2W

DOI: 10.1016/j.etap.2024.104458

Abstract (EN): Biopesticides are natural compounds considered more safe and sustainable for the environment. Spinosad (SPI) is a bioinsecticide used in marketed worldwide, to eradicate a variety of pests. This study aimed to assess the impacts of the SPI on the non-target organism zebrafish (Danio rerio). Several concentrations of SPI were tested to evaluate the acute (0.07-1.0 mg/L) and chronic (0.006-0.100 mg/L) ecotoxicological effects. To evaluate subindividual effects, antioxidant defense, lipid peroxidation, energy sources, and cholinergic biomarkers were quantified. In both exposures, SPI induced significant effects on antioxidant defense indicating oxidative stress, disrupting energy pathways, and exhibiting neurotoxic effects, under environmentally relevant conditions. Integrated Biomarker Response (IBRv2) showed that with increasing SPI concentrations, an increase in impacts on organisms was recorded. This study demonstrates the vulnerability of a non-target organism to SPI, a bioinsecticide considered environmentally safe. Further research is essential to fully understand the implications of spinosad to aquatic biota.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10