Proinflammatory Environment Dictates the IL-17–Producing Capacity of Human Invariant NKT Cells

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Lúcia Moreira-Teixeira (Author) Other; Mariana Resende (Author) Other; Maryaline Coffre (Author) Other; Odile Devergne (Author) Other; Jean-Philippe Herbeuval (Author) Other; Olivier Hermine (Author) Other; Elke Schneider (Author) Other; Lars Rogge (Author) Other; Frank M. Ruemmele (Author) Other; Michel Dy (Author) Other; Anabela Cordeiro da Silva (Author) FFUP; Maria C. Leite-de-Moraes (Author) Other

Journal

Title: Journal of Immunology

Vol. 186 No. 10

Pages: 5758-5765

ISSN: 0022-1767

Publisher: American Association of Immunologists

Indexing

ISI Web of Science

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Resumo (PT): CD1d-reactive invariant NKT (iNKT) cells have been implicated in a number of experimental models of human pathologies. Given the scope of their immunoregulatory activities mediated through distinct cytokine patterns, it has been proposed that this functional diversity originates from distinct iNKT subpopulations. In this study, we report that human CD161+ iNKT cells are intrinsically endowed with the capacity to generate IL-17, but require TGF-β, IL-1β, and IL-23 to carry out this potential. IL-17–producing iNKT cells are already present in cord blood but, in contrast to peripheral blood iNKT cells, they cannot generate IFN-γ. These IL-17 producers respond to aryl hydrocarbon receptor stimulation and express IL-23 receptor and retinoic acid-related orphan receptor C, similar to conventional T helper 17 cells, from which they differ by their restricted ability to coproduce IL-22. In conclusion, IL-17 production by human iNKT cells depends on two critical parameters, namely an intrinsic program and a proinflammatory environment <br> <br> <a target="_blank" href="http://www.jimmunol.org/content/186/10/5758.abstract"> Texto integral </a> <br> <br>

Abstract (EN): CD1d-reactive invariant NKT (iNKT) cells have been implicated in a number of experimental models of human pathologies. Given the scope of their immunoregulatory activities mediated through distinct cytokine patterns, it has been proposed that this functional diversity originates from distinct iNKT subpopulations. In this study, we report that human CD161+ iNKT cells are intrinsically endowed with the capacity to generate IL-17, but require TGF-β, IL-1β, and IL-23 to carry out this potential. IL-17–producing iNKT cells are already present in cord blood but, in contrast to peripheral blood iNKT cells, they cannot generate IFN-γ. These IL-17 producers respond to aryl hydrocarbon receptor stimulation and express IL-23 receptor and retinoic acid-related orphan receptor C, similar to conventional T helper 17 cells, from which they differ by their restricted ability to coproduce IL-22. In conclusion, IL-17 production by human iNKT cells depends on two critical parameters, namely an intrinsic program and a proinflammatory environment <br> <br> <a target="_blank" href="http://www.jimmunol.org/content/186/10/5758.abstract">Full text </a> <br> <br>

Language: English

Type (Professor's evaluation): Scientific