Synthesis and Antimalarial Properties of New Chloro-9H-xanthones with an Aminoalkyl Side Chain

• Type: Article in International Scientific Journal
• Date: 2007

Authors

César Portela (Author) Other; Carlos M. M. Afonso (Author) FFUP; Madalena M. M. Pinto (Author) FFUP; Dinora Lopes (Author) Other; Fátima Nogueira (Author) Other; Virgílio do Rosário (Author) Other

Journal

Title: Chemistry and Biodiversity

Vol. 4 No. 7

Pages: 1508-1519

ISSN: 1612-1872

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 20 Citations

ISI Web of Science

Scopus - 21 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-CQ3

Resumo (PT): The synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones, carrying a [2-(diethylamino)ethyl]amino group in position 1, are reported. All compounds were found to be active towards the chloroquine-susceptible and chloroquine-resistant strains 3D7 and Dd2, resp., of the protozoa parasite Plasmodium falciparum. Especially one compound, 6-chloro-1-{[2-(diethylamino)ethyl]amino}-9H-xanthen-9-one (1k), was found to exhibit significant in vitro activity (IC50=3.9 μM) towards the resistant Dd2 strain <br> <br> Keywords:Antimalaria activity;Plasmodium falciparum;Aminoalkylchloroxanthones;9H-Xanthen-9-ones, chloro- <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790130/abstract"> Texto integral</a> <br> <br>

Abstract (EN): The synthesis and antimalarial properties of twelve new chlorinated 9H-xanthones, carrying a [2-(diethylamino)ethyl]amino group in position 1, are reported. All compounds were found to be active towards the chloroquine-susceptible and chloroquine-resistant strains 3D7 and Dd2, resp., of the protozoa parasite Plasmodium falciparum. Especially one compound, 6-chloro-1-{[2-(diethylamino)ethyl]amino}-9H-xanthen-9-one (1k), was found to exhibit significant in vitro activity (IC50=3.9 μM) towards the resistant Dd2 strain <br> <br> Keywords:Antimalaria activity;Plasmodium falciparum;Aminoalkylchloroxanthones;9H-Xanthen-9-ones, chloro- <br> <a target="_blank" href="http://onlinelibrary.wiley.com/doi/10.1002/cbdv.200790130/abstract">Full text</a> <br> <br>

Language: English

Type (Professor's evaluation): Scientific