Application of pulsed flow analysis for chemiluminescent screening of fluoxetine counterfeit pharmaceuticals

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Karine L Marques (Author) Other; Joao L M Santos (Author) FFUP; Jose L F C Lima (Author) FFUP

Journal

Title: Analytical Letters

Vol. 40 No. 6

Pages: 2241-2251

ISSN: 0003-2719

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 7 Citations

ISI Web of Science

Scopus - 8 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

CORDIS: Health sciences

Other information

Authenticus ID: P-004-CEP

DOI: 10.1080/00032710701566826

Resumo (PT): A chemiluminometric methodology for fluoxetine determination based on its antioxidant scavenger effect on the fast chemiluminescence reaction between luminol and hypochlorite, is proposed. The developed procedure was implemented in a fully automated multi-pumping flow system, combining the excellent mixing characteristics of the pulsed flow with chemiluminescence detection, resulting on a sensitive, simple, and fast procedure for fluoxetine determination in pharmaceutical formulations. Linear calibration plots for fluoxetine hydrochloride concentrations of up to 10 mg l-1 (r=0.9995, n=7) were obtained, with an r.s.d<2% (n=10). Detection limit (3 σ) was 0.31 mg l-1 and the sampling rate was about 136 determinations per h. <br> <br> Keywords: Multi-pumping; chemiluminescence; fluoxetine; luminol; hypochlorite; counterfeit drugs <br> <a target="_blank" href="http://www.informaworld.com/smpp/content~db=all~content=a784415007"> Texto integral</a> <br> <br>

Abstract (EN): A chemiluminometric methodology for fluoxetine determination based on its antioxidant scavenger effect on the fast chemiluminescence reaction between luminol and hypochlorite, is proposed. The developed procedure was implemented in a fully automated multi-pumping flow system, combining the excellent mixing characteristics of the pulsed flow with chemiluminescence detection, resulting on a sensitive, simple, and fast procedure for fluoxetine determination in pharmaceutical formulations. Linear calibration plots for fluoxetine hydrochloride concentrations of up to 10 mg 1(-1) (r = 0.9995, n = 7) were obtained, with an r.s.d < 2% (n = 10). Detection limit (3 sigma) was 0.31 mg 1(-1) and the sampling rate was about 136 determinations per h.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11