Antifungal activity of a gel containing Thymus vulgaris essential oil against Candida species commonly involved in vulvovaginal candidosis

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Jose das Neves (Author) Other; Eugenia Pinto (Author) FFUP; Maria Helena Amaral (Author) FFUP; Maria Fernanda Bahia (Author) Other

Journal

Title: Pharmaceutical Biology

Vol. 47 No. 2

Pages: 151-153

ISSN: 1388-0209

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 16 Citations

ISI Web of Science

Scopus - 19 Citations

Scientific classification

FOS: Engineering and technology > Medical engineering

CORDIS: Health sciences > Pharmacological sciences > Pharmacy

Other information

Authenticus ID: P-003-RM0

DOI: 10.1080/13880200802436232

Resumo (PT): Previous reports of the antifungal potential of Thymus vulgaris L. (Lamiaceae) essential oil against Candida spp. suggests that this natural product may play a valuable role in the management of vulvovaginal candidosis. A polycarbophil-based gel, containing Thymus vulgaris essential oil (1%, w/w), was formulated and its antifungal activity was evaluated in vitro against four strains of Candida commonly involved in vulvovaginal candidosis. Results show that the gel allows the essential oil to maintain its activity at pH values near those observed in the healthy vagina. Also, the lack of significant antifungal activity of the polycarbophil-based gel seems to be advantageous when considering its use as a placebo formulation. Further in vivo studies are needed in order to evaluate the potential of this drug formulation in the management of vulvovaginal candidosis. <br> <br> <a target="_blank" href=" http://web.ebscohost.com/ehost/detail?vid=3&hid=15&sid=a0e87d9a-f2d2-4b36-bd4a-e22083a6dac5%40sessionmgr13&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=a9h&AN=43539220"> Texto integral </a> <br> <br>

Abstract (EN): Previous reports of the antifungal potential of Thymus vulgaris L. (Lamiaceae) essential oil against Candida spp. suggests that this natural product may play a valuable role in the management of vulvovaginal candidosis. A polycarbophil-based gel, containing Thymus vulgaris essential oil (1%, w/w), was formulated and its antifungal activity was evaluated in vitro against four strains of Candida commonly involved in vulvovaginal candidosis. Results show that the gel allows the essential oil to maintain its activity at pH values near those observed in the healthy vagina. Also, the lack of significant antifungal activity of the polycarbophil-based gel seems to be advantageous when considering its use as a placebo formulation. Further in vivo studies are needed in order to evaluate the potential of this drug formulation in the management of vulvovaginal candidosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3