Pre- and postjunctional effects of angiotensin II in hypertension due to adenosine receptor blockade

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Morato, M (Author) FFUP; Pinho, D (Author) Other; Sousa, T (Author) FFUP; Guimaraes, S (Author) Other; Moura, D (Author) FMUP; Albino Teixeira, A (Author) FMUP

Journal

Title: European Journal of Pharmacology

Vol. 531 No. 1

Pages: 209-216

ISSN: 0014-2999

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

ISI Web of Science

Scopus - 6 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences

Other information

Authenticus ID: P-004-N8S

DOI: 10.1016/j.ejphar.2005.12.009

Resumo (PT): Prejunctional facilitation of [3H]noradrenaline release induced by sympathetic nerve stimulation and postjunctional contractile effects of angiotensin II were studied in the mesenteric artery and vein of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX)-hypertensive rats. Male Wistar rats received infusions of saline or DPSPX (90 μg/kg/h) i.p.. Blood pressure was determined by tail-cuff. The prejunctional effect of angiotensin II was similar in artery and vein preparations of control rats and was increased in DPSPX-hypertensive rats. In contrast, the contractile effect of angiotensin II was much more pronounced in the mesenteric vein than in the mesenteric artery of control rats and was markedly reduced in DPSPX-hypertensive rats. We conclude that (1) the increased prejunctional effect of angiotensin II may contribute to, while (2) the decreased contractile effect of angiotensin II may attenuate DPSPX-induced hypertension. This study also supports the hypothesis that pre- and postjunctional angiotensin II receptors are different. <br> <br> Keywords: Angiotensin II; Hypertension; Adenosine receptor blockade <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1J-4J3WSHD-2&_user=2460038&_coverDate=02%2F15%2F2006&_rdoc=33&_fmt=high&_orig=browse&_origin=browse&_zone=rslt_list_item&_srch=doc-info(%23toc%234892%232006%23994689998%23616482%23FLA%23display%23Volume)&_cdi=4892&_sort=d&_docanchor=&_ct=46&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=873d878c1c57f387063dee7b2460256b&searchtype=a">Texto integral</a> <br> <br>

Abstract (EN): Prejunctional facilitation of [H-3]noradrenaline release induced by sympathetic nerve stimulation and postjunctional contractile effects of angiotensin II were studied in the mesenteric artery and vein of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX)-hypertensive rats. Male Wistar rats received infusions of saline or DPSPX (90 mu g/kg/h) i.p.. Blood pressure was determined by tail-cuff. The prejunctional effect of angiotensin II was similar in artery and vein preparations of control rats and was increased in DPSPX-hypertensive rats. In contrast, the contractile effect of angiotensin II was much more pronounced in the mesenteric vein than in the mesenteric artery of control rats and was markedly reduced in DPSPX-hypertensive rats. We conclude that (1) the increased prejunctional effect of angiotensin II may contribute to, while (2) the decreased contractile effect of angiotensin II may attenuate DPSPX-induced hypertension. This study also supports the hypothesis that pre- and postjunctional angiotensin II receptors are different.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8