Chemical composition and biological screening of Capsella bursa-pastoris

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Clara Grosso (Author) Other; Juliana Vinholes (Author) Other; Luis R Silva (Author) Other; de Pinho, PG (Author) FFUP; Rui F Goncalves (Author) Other; Patricia Valentao (Author) FFUP; Anna K Jager (Author) Other; Paula B Andrade (Author) FFUP

Journal

Title: Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Vol. 21 No. 4

Pages: 635-644

ISSN: 0102-695X

Indexing

ISI Proceedings

ISI Web of Knowledge - 34 Citations

Scopus - 50 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

CORDIS: Health sciences > Pharmacological sciences > Pharmacognosy

Other information

Authenticus ID: P-002-PWX

DOI: 10.1590/s0102-695x2011005000107

Resumo (PT): Capsella bursa-pastoris (L.) Medik. (Brassicaceae) is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant), quinic acid (95628.00 mg/kg of dry plant), arginine (mean value of 1.18 mg/kg of dry plant), palmitic acid (284.48 mg/kg) and β-sitosterol (28%). The extracts presented a concentration-dependent antiradical activity (against DPPH•, O2 •- and LOO•), being most effective against •NO (EC25 0.20 μg/mL). In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant’s good nutritional value, it presents important biological properties as well. <br> <br> <a target="_blank" href="http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000400012&lng=pt&nrm=iso&tlng=en"> Texto integral </a> <br> <br>

Abstract (EN): Capsella bursa-pastoris (L.) Medik. (Brassicaceae) is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant), quinic acid (95628.00 mg/kg of dry plant), arginine (mean value of 1.18 mg/kg of dry plant), palmitic acid (284.48 mg/kg) and beta-sitosterol (28%). The extracts presented a concentration-dependent antiradical activity (against DPPH center dot, O-2(center dot-) and LOO center dot), being most effective against (NO)-N-center dot (EC25 0.20 mu g/mL). In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant's good nutritional value, it presents important biological properties as well.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10