Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Cristiane M Cazal (Author) Other; Kantima Choosang (Author) Other; Vanessa Gisele P Severino (Author) Other; Marcio S Soares (Author) Other; Andre Lucio F Sarria (Author) Other; Joao B Fernandes (Author) Other; Maria Fatima G F Silva (Author) Other; Paulo Cezar Vieira (Author) Other; Pannee Pakkong (Author) Other; Gabriela M Almeida (Author) Other; Helena Vasconcelos, MH (Author) FFUP; Maria S J Nascimento (Author) FFUP; Madalena M M Pinto (Author) FFUP

Journal

Title: Anti-Cancer Agents in Medicinal Chemistry

Vol. 10 No. 10

Pages: 769-776

ISSN: 1871-5206

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 21 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-0AE

Abstract (EN): Six triterpenes and eight limonoids were evaluated for their capacity to inhibit the growth of three human tumour cell lines, breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). The mechanisms involved in the observed cell growth arrest of the four most potent compounds were carried out by studying their effect in cell cycle profile and programmed cell death. The results showed that one triterpene (odoratol) and two limonoids (gedunin and cedrelone) caused cell cycle arrest while only the limonoids gedunin and cedrelone were found to be very potent inducers of apoptosis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8