Altered alanine aminotransferase and gamma-glutamyl transpeptidase in women with history of preeclampsia: association with waist-to-hip ratio and body mass index

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Ana Portelinha (Author) Other; Ana Sofia Cerdeira (Author) Other; Luis Belo (Author) FFUP; Eduardo Tejera (Author) Other; Fatima Pinto (Author) Other; Ana Pinto (Author) Other; Irene Rebelo (Author) FFUP

Journal

Title: European Journal of Gastroenterology & Hepatology

Vol. 21 No. 2

Pages: 196-200

ISSN: 0954-691X

Publisher: Lippincott Williams & Wilkins

Indexing

ISI Web of Knowledge - 2 Citations

ISI Web of Science

Scopus - 3 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

CORDIS: Health sciences

Other information

Authenticus ID: P-003-NDZ

DOI: 10.1097/MEG.0b013e32831d81a7

Resumo (PT): Objective: Preeclampsia (PE), mostly when associated with HELLP syndrome, together with acute fatty liver of pregnancy, are the main causes of severe hepatic failure in pregnancy. Despite the number of studies in pregnancies complicated with PE, there are a few studies that focused on the evaluation of the hepatic function of these women several years after delivery. In this way, we evaluated circulating levels of AST, ALT, [gamma]GT and CRP several years after preeclamptic pregnancy to verify if these parameters are altered. Methods: Eighty-nine women with previous PE and 60 women without medical complications were invited to the research centers. After the physical examination, blood was drawn for biochemical measurements. Plasma CRP levels and serum concentration of AST, ALT, [gamma]GT were measured by automated enzymatic assays. Results: Systolic and diastolic blood pressures were significantly higher in women with history of PE than in control group as well as BMI and waist-to-hip ratio. ALT and [gamma]GT were significantly higher in women with previous history of PE, whereas AST and CRP presented similar levels between the two groups. Data revealed statistically significant positive correlations between ALT and [gamma]GT with waist-to-hip ratio and BMI. Positive correlations were also found between BMI and AST and CRP. Conclusion: It is possible that the increase in ALT and [gamma]GT levels is due to being overweight or through accumulation of visceral fat. Unaltered values of CRP suggest that the higher ALT and [gamma]GT values found in women with history of PE are not associated with inflammation. <br> <br> Keywords: body mass index, hypertension, liver, preeclampsia <br> <a target="_blank" href="http://ovidsp.tx.ovid.com/sp-2.3.1b/ovidweb.cgi?&S=BGDOFPFIBHDDLNPNNCDLLHCKEGNFAA00&Link+Set=S.sh.15.17.22.45%7c10%7csl_10"> Texto integral </a> <br> <br>

Abstract (EN): Objective Preeclampsia (PE), mostly when associated with HELLP syndrome, together with acute fatty liver of pregnancy, are the main causes of severe hepatic failure in pregnancy. Despite the number of studies in pregnancies complicated with PE, there are a few studies that focused on the evaluation of the hepatic function of these women several years after delivery. In this way, we evaluated circulating levels of AST, ALT, gamma GT and CRP several years after preeclamptic pregnancy to verify if these parameters are altered. Methods Eighty-nine women with previous PE and 60 women without medical complications were invited to the research centers. After the physical examination, blood was drawn for biochemical measurements. Plasma CRP levels and serum concentration of AST, ALT, gamma GT were measured by automated enzymatic assays. Results Systolic and diastolic blood pressures were significantly higher in women with history of PE than in control group as well as BMI and waist-to-hip ratio. ALT and gamma GT were significantly higher in women with previous history of PE, whereas AST and CRP presented similar levels between the two groups. Data revealed statistically significant positive correlations between ALT and gamma GT with waist-to-hip ratio and BMI. Positive correlations were also found between BMI and AST and CRP. Conclusion It is possible that the increase in ALT and gamma GT levels is due to being overweight or through accumulation of visceral fat. Unaltered values of CRP suggest that the higher ALT and gamma GT values found in women with history of PE are not associated with inflammation. Eur J Gastroenterol Hepatol 21:196-200 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

Language: English

Type (Professor's evaluation): Scientific