Three minimal sequences found in Ebola virus genomes and absent from human DNA

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Silva, RM (Author) Other; Pratas, D (Author) Other; Castro, L (Author) FCUP; Pinho, AJ (Author) Other; Ferreira, PJSG (Author) Other

Journal

Title: Bioinformatics

Vol. 31

Pages: 2421-2425

ISSN: 1367-4803

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 37 Citations

Other information

Authenticus ID: P-00G-FH1

DOI: 10.1093/bioinformatics/btv189

Abstract (EN): Motivation: Ebola virus causes high mortality hemorrhagic fevers, with more than 25 000 cases and 10 000 deaths in the current outbreak. Only experimental therapies are available, thus, novel diagnosis tools and druggable targets are needed. Results: Analysis of Ebola virus genomes from the current outbreak reveals the presence of short DNA sequences that appear nowhere in the human genome. We identify the shortest such sequences with lengths between 12 and 14. Only three absent sequences of length 12 exist and they consistently appear at the same location on two of the Ebola virus proteins, in all Ebola virus genomes, but nowhere in the human genome. The alignment-free method used is able to identify pathogen-specific signatures for quick and precise action against infectious agents, of which the current Ebola virus outbreak provides a compelling example.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5