Triarylphosphonium compounds as effective vectors for mitochondria-targeted delivery systems: decoration strategies and prospects for clinical application

• Type: Another Publication in an International Scientific Journal
• Date: 2023

Authors

Pashirova, TN (Author) Other; Nemtarev, AV (Author) Other; Souto, EB (Author) FFUP; Mironov, VF (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: RUSSIAN CHEMICAL REVIEWS

Vol. 92

ISSN: 0036-021X

Publisher: ND Zelinsky Inst Organic Chemistry, RAS - ZIOC RAS

Indexing

ISI Web of Knowledge - 1 Citation

Other information

Authenticus ID: P-00Z-JVY

DOI: 10.59761/rcr5095

Abstract (EN): Mitochondrial dysfunctions lead to the emergence and development of a large number of diseases. The present review gives the first systematic survey of various aspects of studies of mitochondria-targeted nanosystems that contain triphenylphosphonium vector groups providing targeted delivery of drug substances to these organelles. Approaches to the design of components and various nanoparticles bearing these groups are summarized and analyzed. The relationship between the key parameters of triphenylphosphonium nanoparticles (chemical composition, size, shape, zeta-potential, drug loading, drug encapsulation efficiency, etc.) and the biological action is discussed; in some cases, the mechanism of mitochondria targeting is given. The design principles and preparation methods for mitochondria-targeted triphenylphosphonium delivery nanosystems are of interest to researchers in the field of nanomaterials, nanotechnology, molecular biology, biotechnology and pharmaceutical chemistry.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 55