Nanomaterials-combined methacrylated gelatin hydrogels (GelMA) for cardiac tissue constructs

• Type: Another Publication in an International Scientific Journal
• Date: 2024

Authors

Lisboa, ES (Author) Other; Serafim, C (Author) Other; Santana, W (Author) Other; dos Santos, VLS (Author) Other; de Albuquerque, RLC Jr (Author) Other; Chaud, MV (Author) Other; Cardoso, JC (Author) Other; Jain, S (Author) Other; Severino, P (Author) Other; Souto, EB (Author) FFUP

Journal

Title: Journal of Controlled Release

Vol. 365

Pages: 617-639

ISSN: 0168-3659

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00Z-EVJ

DOI: 10.1016/j.jconrel.2023.11.056

Abstract (EN): Among non-communicable diseases, cardiovascular diseases are the most prevalent, accounting for approximately 17 million deaths per year. Despite conventional treatment, cardiac tissue engineering emerges as a potential alternative for the advancement and treatment of these patients, using biomaterials to replace or repair cardiac tissues. Among these materials, gelatin in its methacrylated form (GelMA) is a biodegradable and biocompatible polymer with adjustable biophysical properties. Furthermore, gelatin has the ability to replace and perform collagen-like functions for cell development in vitro. The interest in using GelMA hydrogels combined with nanomaterials is increasingly growing to promote the responsiveness to external stimuli and improve certain properties of these hydrogels by exploring the incorporation of nanomaterials into these hydrogels to serve as electrical signaling conductive elements. This review highlights the applications of electrically conductive nanomaterials associated with GelMA hydrogels for the development of structures for cardiac tissue engineering, by focusing on studies that report the combination of GelMA with nanomaterials, such as gold and carbon derivatives (carbon nanotubes and graphene), in addition to the possibility of applying these materials in 3D tissue engineering, developing new possibilities for cardiac studies.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 23